ICELISA na przeciwciało monoklonalne do badania przesiewowego
Strukturalny wpływ glikodendrymerów rekrutujących przeciwciała (ARG) na cytotoksyczność przeciwnowotworową
Rekrutacja endogennych przeciwciał przeciwko komórkom rakowym stała się niezawodną przeciwnowotworową alternatywą immunoterapeutyczną w ciągu ostatniej dekady. Rzeczywiście wykazano, że kowalencyjne przyłączenie przeciwciał i modułów wiążących nowotwór (ABM i TBM) w jednej, dobrze zdefiniowanej syntetycznej cząsteczce sprzyja tworzeniu się oddziałującego trójskładnikowego kompleksu między przeciwciałami a komórką docelową, co zwykle skutkuje jednoczesnym zniszczenie komórek za pośrednictwem układu odpornościowego. We wstępnym badaniu opisaliśmy pierwsze glikodendrymery rekrutujące przeciwciała (ang. Antibody Recruiting Glycodendrimers, ARG), łączące cRGD jako ligandy dla linii komórkowej czerniaka M21 i Rha z ekspresją αVβ3 jako ligand naturalnej IgM, i wykazaliśmy, że wielowartościowość jest niezbędnym warunkiem powstania tego kompleksu. .
W niniejszym badaniu zsyntetyzowaliśmy nową serię ARG składających się z ABM, tj. Samoskondensowanych ramnozylowanych cyklopeptydów i dendrymerów polilizynowych, które zostały sprzężone z TBM z lub bez odstępnika. Eksperymenty z cytometrią przepływową i mikroskopią konfokalną z ludzką surowicą i różnymi liniami komórkowymi ujawniły, że geometria ABM znacząco wpływa na tworzenie trójskładnikowego kompleksu w M21, podczas gdy w BT 549 o niskiej ekspresji integryny nie występuje żadne znaczące wiązanie.
Ponadto wykazujemy za pomocą testu żywotności komórek , że ARG indukują wysoki poziom cytotoksyczności wobec M21, co jest również w ścisłej korelacji ze strukturą ABM. W szczególności wykazaliśmy, że ARG łączący rdzeń cyklopeptydowy i rozgałęzienia, z lub bez przerywnika, indukuje 40-57% selektywnej cytotoksyczności wobec komórek M21 w obecności ludzkiej surowicy jako wyjątkowego źródła efektorów odporności. Na koniec podkreślamy również, że odstępnik między ABM i TBM umożliwia zwiększenie cytotoksyczności pośredniczonej przez układ odpornościowy, nawet przy ABM o niższej wartościowości.
Description: Cytokeratin 6 is an epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. This protein always paired with the type-I keratin K16. Cytokeratin 6 have been identified in epidermis only in samples from plantar glabrous skin while in hairy skin this keratin appeared to be absent in interfollicular epidermis but were clearly present in hair follicle outer root sheath, and this protein also consistently expressed in non-keratinizing stratified squamous epithelia. Among tumors, cytokeratin 6 is typically and strongly expressed in squamous cell carcinomas of different sites, preferentially in inner, maturing layers of the tumor cell nests. Cytokeratin 6 is always used with cytokeratin 5 and is a useful aid for classification of epithelioid mesotheliomas.
Description: Cytokeratin 6 is an epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. This protein always paired with the type-I keratin K16. Cytokeratin 6 have been identified in epidermis only in samples from plantar glabrous skin while in hairy skin this keratin appeared to be absent in interfollicular epidermis but were clearly present in hair follicle outer root sheath, and this protein also consistently expressed in non-keratinizing stratified squamous epithelia. Among tumors, cytokeratin 6 is typically and strongly expressed in squamous cell carcinomas of different sites, preferentially in inner, maturing layers of the tumor cell nests. Cytokeratin 6 is always used with cytokeratin 5 and is a useful aid for classification of epithelioid mesotheliomas.
Description: Cytokeratin 6 is an epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. This protein always paired with the type-I keratin K16. Cytokeratin 6 have been identified in epidermis only in samples from plantar glabrous skin while in hairy skin this keratin appeared to be absent in interfollicular epidermis but were clearly present in hair follicle outer root sheath, and this protein also consistently expressed in non-keratinizing stratified squamous epithelia. Among tumors, cytokeratin 6 is typically and strongly expressed in squamous cell carcinomas of different sites, preferentially in inner, maturing layers of the tumor cell nests. Cytokeratin 6 is always used with cytokeratin 5 and is a useful aid for classification of epithelioid mesotheliomas.
Description: This MAb recognizes a protein of 56kDa, identified as cytokeratin 6A (KRT6A). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns. Cytokeratin 6A is the dominant form in epithelial tissue. Cytokeratin 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Cytokeratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express KRT6 and KRT16. KRT6 is strongly expressed in about 75% of head and neck squamous cell carcinomas.
Description: This MAb recognizes a protein of 56kDa, identified as cytokeratin 6A (KRT6A). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns. Cytokeratin 6A is the dominant form in epithelial tissue. Cytokeratin 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Cytokeratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express KRT6 and KRT16. KRT6 is strongly expressed in about 75% of head and neck squamous cell carcinomas.
Description: This MAb recognizes a protein of 56kDa, identified as cytokeratin 6A (KRT6A). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns. Cytokeratin 6A is the dominant form in epithelial tissue. Cytokeratin 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Cytokeratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express KRT6 and KRT16. KRT6 is strongly expressed in about 75% of head and neck squamous cell carcinomas.
Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 7A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 7A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 7A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 3
in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 3
in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 3
in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse Semaphorin 4D in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse Semaphorin 4D in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse Semaphorin 4D in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse Semaphorin 6D in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse Semaphorin 6D in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse Semaphorin 6D in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse semaphorin 3G in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse semaphorin 3G in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse semaphorin 3G in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A polyclonal antibody for detection of Rab 6A from Human, Mouse, Rat. This Rab 6A antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Rab 6A at AA range: 90-170
Description: A polyclonal antibody for detection of Rab 6A from Human, Mouse, Rat. This Rab 6A antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Rab 6A at AA range: 90-170
Description: A polyclonal antibody for detection of Rab 6A from Human, Mouse, Rat. This Rab 6A antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Rab 6A at AA range: 90-170
ICELISA na przeciwciało monoklonalne do badania przesiewowego diazynonu w próbkach warzyw
Diazynon (DAZ) to pestycyd fosforoorganiczny (OP), który jest powszechnie stosowany do zapobiegania i zwalczania szkodników zagrażających produktom rolnym. W tym badaniu opracowaliśmy nowatorską strategię powlekania heterologicznego do testu immunologicznego DAZ. DAZ hapten powłoka może być bezpośrednio sprzężone z białkiem nośnikowym, bez konieczności ramię przekładki. Ta proponowana strategia powlekania haptenem oszczędza czas i znacznie poprawia czułość testu immunologicznego z powodu braku ramienia rozdzielającego. AS syntetyzuje się powlekanie antygenu zastosowano do przeszukania przeciwciała monoklonalne (mAb).
Wreszcie rozwinięty pośredni konkurencyjny check immunoenzymatyczny (icELISA) wykazała układu scalonego 50 , a granica wykrywalności (LOD) wartości 0,58 ng ml -1 i eight str ml -1 , odpowiednio. Metoda ta wykazywała pomijalną reaktywność krzyżową z innymi analogami, a odzysk próbek (ogórek, kapusta i sałata) wahał się od 92,6% do 125,4%, ze współczynnikami wariancji (CV) poniżej 12%. Uzyskano dobrą korelację między icELISA a wysokosprawną chromatografią cieczową ze spektrometrią mas (HPLC-MS / MS) . Proponowany icELISA był idealnym narzędziem do monitorowania pozostałości DAZ w próbkach żywności.
Przeciwciała przeciwko dekarboksylazie glutaminianowej w surowicy a zaburzenia neurologiczne: kiedy podejrzewać ich związek?
Cele: Zbadanie różnych objawów neurologicznych z podejrzeniem ich powiązania z przeciwciałami dekarboksylazy glutaminianu w surowicy (GAD-Abs) , aby lepiej scharakteryzować neurologiczne zespoły anty-GAD.
Metody: Obserwacyjne badanie retrospektywne obejmujące wszystkich pacjentów, u których miano GAD65-Abs w surowicy zostało zlecone przez Oddział Neurologii Szpitala Uniwersyteckiego La Paz w latach 2015–2019. GAD-Abs mierzono metodą ELISA. Badano dane demograficzne, objawy neurologiczne, współwystępowanie z cukrzycą (DM) lub inną chorobą autoimmunologiczną oraz miana GAD-Abs . Zespół sztywności, ataksja, zapalenie mózgu i epilepsja uznano za typowe neurologiczne zespoły przeciw GAD i porównano je z innymi nietypowymi objawami.
Wyniki: Łącznie uwzględniono 173 pacjentów (51,7% mężczyzn, średni wiek 51,62 lat) . W ciągu ostatnich 5 lat obserwowano postępujący wzrost żądań GAD-Abs w surowicy, zwłaszcza u pacjentów z atypowymi objawami neurologicznymi. GAD-Abs stwierdzono w surowicy 22 pacjentów (12,7%); spośród nich 15 (68,18%) miało typowy zespół anty-GAD. Obecność DM lub innej specyficznej narządowej choroby autoimmunologicznej była czynnikiem predykcyjnym dla seropozytywności GAD-AB (p <0,001). 6,6% badanych pacjentów z zespołem atypowym miało GAD-Abs, ale poziomy w surowicy były znacznie niższe niż u pacjentów z typowym zespołem (706,67 vs 1430,23 UI / ml; Mann-Whitney U, p = 0,034) i ostatecznie zdiagnozowano inną chorobę neurologiczną.
Wniosek: GAD-Ab w surowicy rzadko wykrywano u pacjentów z fenotypami klinicznymi innymi niż te klasycznie określane jako zaburzenia anty-GAD oraz z bardzo niskimi mianami. W typowych zespołach przeciw GAD występuje duża współwystępowanie z DM i innymi chorobami autoimmunologicznymi, przy czym zwykle występuje wysoki poziom GAD-Abs w surowicy.
Błąd połączenia.
Podwójne dodatnie przeciwciało przeciwko β 2 -glikoproteinie I domenie I i przeciw fosfatydyloserynie / protrombinie wzmacnia sygnał zakrzepicy, jak i dodatni wynik przeciwciał anty-ADAMTS13
Chociaż w przypadku nabytej zakrzepowej plamicy małopłytkowej (TTP) występuje kilka zespołów antyfosfolipidowych (APS), związek między przeciwciałami antyfosfolipidowymi (aPL) a przeciwciałami anty-ADAMTS13 (anty-dezintegrynie i metaloproteazą z motywem trombospondyny typu 1 , członek 13) pozostaje niepewny. Zbadaliśmy związek między zakrzepową aPL wysokiego ryzyka a przeciwciałem anty-ADAMTS13. Uwzględniono dwustu trzydziestu siedmiu pacjentów z dodatnim wynikiem antykoagulantu toczniowego i / lub przeciwciał antykardiolipinowych. Anty-β 2 GPI (anty-β 2- glikoproteina I), anty-β 2 GPIdI (anty-β2-glikoproteina I domena I), anty-PS / PT (anty-fosfatydyloseryna i protrombina), aktywność ADAMTS13 i anty- Zmierzono poziom przeciwciał ADAMTS13 .Podwójne dodatnie wyniki przeciwciał anty-β 2 GPI i anty-PS / PT zwiększały ryzyko zakrzepicy ponad trzykrotnie i wykazywały zwiększoną dodatnią aktywność przeciwciał anty-ADAMTS13 w porównaniu z grupą podwójnie ujemną.
Podwójna dodatnia skuteczność anty-β 2 GPIdI i anty-PS / PT wykazała oba efekty jeszcze bardziej. W liniowej analizy regresji dwukrotnie dodatni anty-beta 2 GPI i anty-PS / Pt niezależnie wpływ anty-ADAMTS13 poziomu przeciwciał (p = 1.982; p = 0,042) . Nasze wyniki ujawniły, że podwójna dodatnia wartość anty-β 2 GPI lub anty-β 2 GPIdI i anty-PS / PT zwiększyła nie tylko ryzyko zakrzepicy, ale także dodatni wynik przeciwciał anty-ADAMTS13, szczególnie wskazujący na wyższą synergię anty-β 2 GPIdI. efekt z anty-PS / PT. Sugerujemy możliwy związek przeciwciała anty-ADAMTS13 z wysokim ryzykiem zakrzepicy APS.
Podwójnie dodatnie przeciwciała anty-β 2 GPI (anty-β 2- glikoproteina I) i anty-PS / PT (przeciw fosfatydyloserynie i protrombinie) zwiększały nie tylko ryzyko zakrzepicy, ale także dodatnie wyniki anty-ADAMTS13 (anty-dezintegryna i metaloproteaza) z motywem trombospondyny typu 1, członek 13) przeciwciało. Ponadto, podwójna dodatnia aktywność anty-β 2 GPIdI (domena I anty-β2-glikoproteiny I) w połączeniu z anty-PS / PT jeszcze bardziej zwiększała zarówno zakrzepicę, jak i dodatni wynik przeciwciał przeciwko ADAMTS13. Podwójna pozytywność β 2 GPIa anty-PS / PT stwierdzono jako niezależnie istotny czynnik przyczyniający się do poziomu przeciwciał anty-ADAMTS13. Sugerujemy związek między przeciwciałem anty-ADAMTS13 a patofizjologią zespołu antyfosfolipidowego , który należy poddać dalszej ocenie.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Nitrotyrosine (NT) in samples from serum, plasma, tissue homogenates or other biological fluids.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Nitrotyrosine (NT) in samples from serum, plasma, tissue homogenates or other biological fluids.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat Neurotensin (NT) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat Neurotensin (NT) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Description: NT-3 is a protein encoded by the NTF3 gene which is approximately 29,4 kDa. NT-3 is secreted and is involved in apoptotic pathways in synovial fibroblasts, the GPCR pathway, ERK signalling, TGF-beta pathway and nanog in mammalian ESC pluripotency. This protein falls under the neurotrophin family. It controls survival and differentiation of mammalian neurons and is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo. NT-3 is expressed in the brain and peripheral tissues. Mutations in the NTF3 gene result in diabetic neuropathy and pediatric fibrosarcoma. STJ98718 was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. This polyclonal antibody binds to endogenous NT-3.
Description: A sandwich quantitative ELISA assay kit for detection of Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit
Description: The plasma concentrations of both the N-terminal fragment of Pro-B-type natriuretic peptide (NT-proBNP) and prohormone of brain natriuretic peptide (proBNP) are significantly increased in patients with asymptomatic and symptomatic left ventricular dysfunction.
Description: The plasma concentrations of both the N-terminal fragment of Pro-B-type natriuretic peptide (NT-proBNP) and prohormone of brain natriuretic peptide (proBNP) are significantly increased in patients with asymptomatic and symptomatic left ventricular dysfunction.
Description: NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers (240 total amino acid residues). Human and Mouse NT-3 sequences are identical.
Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) ELISA Kit
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) in samples from serum, plasma, tissue homogenates or other biological fluids.
Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) ELISA Kit
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) in samples from serum, plasma, tissue homogenates or other biological fluids.
Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) ELISA Kit
Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin-3, NT-3 in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin-3, NT-3 in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Description: Quantitativesandwich ELISA kit for measuring Human 3-nitrotyrosine (3-NT) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Description: Quantitativesandwich ELISA kit for measuring Human 3-nitrotyrosine (3-NT) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Description: Neurotrophin-3 Human Recombinant produced in E.Coli is a non-glycosylated and non-covalently linked homodimer, containing 2x119 amino acid chains, having a total Mw of 27.2 kDa.;The NT-3 is purified by proprietary chromatographic techniques.
Description: NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers (240 total amino acid residues). Human and Mouse NT-3 sequences are identical.
Description: NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers (240 total amino acid residues). Human and Mouse NT-3 sequences are identical.
Description: NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers (240 total amino acid residues).Human and Mouse NT-3 sequences are identical.
Description: A polyclonal antibody for detection of NT-3 from Human, Mouse, Rat. This NT-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human NT-3 protein at amino acid sequence of 180-230
Description: A polyclonal antibody for detection of NT-3 from Human, Mouse, Rat. This NT-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human NT-3 protein at amino acid sequence of 180-230
Description: A polyclonal antibody for detection of NT-3 from Human, Mouse, Rat. This NT-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human NT-3 protein at amino acid sequence of 180-230
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NT-3 . This antibody is tested and proven to work in the following applications:
Description: A sandwich quantitative ELISA assay kit for detection of Mouse N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Mouse N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Mouse N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Rat N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Rat N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) in samples from serum, plasma, tissue homogenates or other biological fluids.
Rat N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Rat N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) in samples from serum, plasma, tissue homogenates or other biological fluids.
Canine N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit
Description: A competitive inhibition quantitative ELISA assay kit for detection of Canine N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Canine N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit
Description: A competitive inhibition quantitative ELISA assay kit for detection of Canine N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Mouse N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Mouse N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Mouse N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Mouse N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Porcine N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Porcine N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) in samples from serum, plasma or other biological fluids.
Porcine N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Porcine N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) in samples from serum, plasma or other biological fluids.
Rat N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Rat N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Rat N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Rat N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Rabbit N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) in samples from serum, plasma, tissue homogenates or other biological fluids.
Rabbit N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Rabbit N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) in samples from serum, plasma, tissue homogenates or other biological fluids.
Mouse N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit
